Anti-tuberculosis activity of Rivaroxabane in silico and in vitro

The activity of Rivaroxoban oxazolidinone series against Mycobacterium terrae was investigated in silico and vitro. In studies have shown a high binding affinity Rivaroxaban to β-ketoacyl[ACP]synthase I that plays key role the biosynthesis mycolic acids, being components mycobacterial cell wall. molecular docking study, two main sites with protein were predicted evaluated: minimum energies found for both values –10.26 kcal/mol –8.99 kcal/mol. A solution (200 μg/ml) has been inhibit growth culture. data obtained open up prospect developing new effective anti-tuberculosis drugs series.